Identification of cognitive subtypes in AD using a statistical clustering
 
   Lead Investigator:    Wiesje van der Flier
   Institution      :    VU University Medical Center
   E-Mail           :    wm.vdflier@vumc.nl
   Proposal ID      :    618



   Proposal Description:
   We aim to identify cognitive subtypes (at least two: memory profile versus        non-memory profile) in AD patients, using a bottom-up, clustering approach        based on all available neuropsychological test results.                           We will apply non-negative matrix factorisation (NMF), which is a clustering      approach implemented in the statistical software package R.                       We will use this approach in five separate data sets, i.e. Amsterdam Dementia     COhort, San Francisco Dementia cohort, ADNI, German Competence Network, NACC.     Subsequently, subtypes will be compared for demographics, clinical variables      and APOE genotype.